Search results for "One-Pot synthesis"

One-pot synthesis of graphene quantum dots and simultaneous nanostructured self-assembly via a novel microwave-assisted method: impact on triazine re…

2018

One-step methods for fabricating green materials endowed with diverse functions is a challenge to be overcome in terms of reducing environmental risk and cost. We report a fast and easy synthesis of multifunctional materials composed of only fluorescent dots with structural flexibility and high sorption capability. The synthesis consists of a one-pot microwave-assisted reaction for the simultaneous formation of graphene quantum dots (GQDs) from organic precursors and their spontaneous self-assembly forming porous architectures. The GQD-assemblies are robust and no signs of degradation were observed with most organic solvents. The ensuing GQDs and their porous solids were fully characterized…

Modular one-pot synthesis of tetrasubstituted pyrroles from alpha-(alkylideneamino)nitriles.

2007

2,3,4,5-Tetrasubstituted pyrroles have been prepared with high regioselectivity by a formal cycloaddition of alpha-(alkylideneamino)nitriles and nitroolefins followed by elimination of HCN and HNO2. The reaction allows the convergent construction of the pyrrole ring in four steps from a nitroalkane and three aldehydes.

ChemInform Abstract: Selective “One-Pot” Synthesis of Functionalized Cyclopentenones.

2012

Reaction of squaric acid derivatives with vinyl magnesium bromide followed by treatment with trifluoroethanol allows a new and stereoselective access to functionalized cyclopentenones of type (III)/ (V).

Rapid one-pot synthesis of tapered star copolymers via ultra-fast coupling of polystyryllithium chain ends

2019

Highly efficient stoichiometric coupling of sterically hindered polystyryllithium (PS-Li) chain ends was achieved using tetra[3-(chloro-dimethylsilyl)propyl]silane (TCDMSPS) as the linking agent. Based on the disparate reactivities of isoprene (I, rI = 11.0) and styrene (S, rS = 0.049) in the anionic copolymerization in nonpolar media, poly(isoprene0.5-grad-styrene0.5) (P(I0.5-grad-S0.5)) tapered 4-arm star copolymers were synthesized in only two steps. The tapered 4-arm star copolymers (Mtargetedw = 40 to 160 kg mol−1) were synthesized with high star functionalities f (Mw,star/Mw,arm = 3.68–3.98), low dispersity (Đ = 1.06–1.15) and minimal residual precursor content (2–8 wt%), avoiding fra…

One‐Pot Synthesis of a New High‐Aluminium‐Content Super‐Microporous Aluminosilicate

2006

A new super-microporous aluminosilicate having a high aluminium content (Si/Al ca. 1) has been prepared through a surfactant-assisted procedure with the use of a commercially available binary precursor (di-sec-butoxyaluminooxytriethoxysilane) as a single source of both Al and Si. The formation of super-micropores is a result of a significant network shrinkage associated with the thermal elimination of the surfactant. This solid has been studied by X-ray powder diffraction, electron microscopy, nuclear magnetic resonance spectroscopy and porosimetry. A preliminary analysis of the acidity and the catalytic activity of the super-microporous solid for the selective catalytic reduction of NOx is…

One-Pot Synthesis to Quinone-Based Diaza[3.3]cyclophanes

2017

A simple one-pot synthesis to [3.3]cyclophanes that involves quinone moieties was found. The protocol tolerates a variety of amines that include aliphatic and aromatic structures with different functional groups, such as hydroxy groups, amides, and terminal double and triple bonds. The straightforward synthesis can be performed by a twofold N-alkylation reaction with 2,5-bis(bromomethyl)-3,6-dimethyl-1,4-benzoquinone (1). Neither anhydrous nor inert conditions are required. Various amines can be employed without any activating groups, several functionalities at end groups are tolerated, and the cyclophanes generated can be easily modified or embedded into larger molecular architectures. The…

A ONE-POT SYNTHESIS OFNαBENZYLOXYCARBONYLNω-t-BUTOXYCARBONYL-L-ORNITHINE AND L-LYSINE

1992

Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (…

2022

Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid or neat acetic acid to afford a novel pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved to be efficient, with a shorter reaction time and high chemical yield with broad substrates. The new pyrazolyl-s-triazine derivatives were tested against the following cell lines: MCF-7 (breast cancer); MDA-MB-231 (tr…

One-Pot Synthesis of Pyrrole-2-carboxylates and -carboxamides via an Electrocyclization/Oxidation Sequence

2014

An electrocyclic ring closure is the key step of an efficient one-pot method for the synthesis of pyrrole-2-carboxylates and -carboxamides from chalcones and glycine esters or amides. The 3,4-dihydro-2H-pyrrole intermediates generated in situ are oxidized to the corresponding pyrroles by stoichiometric oxidants or by catalytic copper(II) and air in moderate to high yields. A wide range of functional groups are tolerated, and further combination with an in situ bromination gives access to polyfunctional pyrrole scaffolds.

N-Heterocyclic Carbene Catalyzed [3+2] Cycloaddition of Enals with Masked Cinnamates for the Asymmetric One-Pot Synthesis of Adipic Acid Derivatives.

2017

A novel short entry to 3,4-disubstituted adipic acids has been developed by employing an asymmetric NHC-catalyzed [3+2] cycloaddition of enals with masked cinnammates in moderate to good yields and high stereoselectivities. The synthetic utility of the protocol was demonstrated by the basic conversion of the masked cyclopentanone intermediates to 3S,4S-disubstituted adipic acid precursors of pharmaceutically important gababutins.